
Otay Mesa Vacations from $305
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
The Latest Otay Mesa Vacation Packages
Price found within the past 48 hours. Click for updated prices.

The Sofia Hotel
Downtown San Diego
Save 100% on your flight
Price was $493, price is now $305 per person
$305
per person
Jan 14 - Jan 16
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (2,743 reviews)
Such a wonderful trip to San Diego and the Sofia was lovely. Close to restaurants and venues and coming back to a clean comfy room was so nice. The view was also beautiful.
Reviewed on Nov 12, 2026



Southern California Beach Club
Townsite
Save 100% on your flight
Price was $978, price is now $655 per person
$655
per person
Feb 1 - Feb 6
found 23 hours ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.2/10 Wonderful! (571 reviews)
We loved staying right at the beach. We got a 1-bedroom room with an ocean view for two of us, and it was amazing. The Strand is a little busy, but bearable. Great value for the money. Will stay here again.
Reviewed on Nov 9, 2026

The Lodge at Torrey Pines
Torrey Pines
Price was $1,839, price is now $1,267 per person
$1,267
per person
Dec 26 - Dec 30
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.4/10 Exceptional! (1,000 reviews)
The property was beautiful and the staff was very friendly and accommodating with our dog. We will definitely be back!
Reviewed on Nov 6, 2026
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

Downtown San Diego
3 out of top 10 points of interest in this area
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
$130 nightly
The price is $148 total per night from Dec 13 to Dec 14
$148 total
Dec 13 - Dec 14
Total with taxes and fees

Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
8.4/10 Very Good! (6,370 reviews)
"The Wyndham San Diego Bayside is very conveniently located. The staff were very welcoming and helpful. The rooms were spacious and comfortable. We loved the walkability to the cruise pier, Little Italy, Seaport Village and transit was close by to get to many points of interest. Highly recommend this ..."
Reviewed on Nov 12, 2026

Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do

Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend

Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
82% of travellers recommend
Explore a world of travel with Expedia
- Kaiser Permanente Otay Mesa Medical Offices
- Balboa Park Carousel
- Ski Beach
- Seaport Village
- San Diego Yacht Club
- Presidio Park
- A National Salute to Bob Hope & the Military
- San Diego Automotive Museum
- Casa de Estudillo
- Coronado Beach
- Our Lady of the Rosary Catholic Church
- Chula Vista Elite Athlete Training Center
- Mccoy Museum House
- San Diego-Coronado Bridge
- San Diego Hall of Champions Sports Museum
- Adams Avenue Park
- Glorietta Bay Park Beach
- Casa de Balboa
- San Diego Opera
- Coronado Shopping Plaza Shopping Center
- Point Loma Nazarene University
- San Diego Natural History Museum
- Botanical Building
- Timken Museum of Art
- The Rady Shell at Jacobs Park
- Firehouse Museum
- Old Town San Diego Vacations
- Mission Valley Vacations
- Eastlake Country Club
- Marston House
- Alcazar Garden
- New Children's Museum
- Heritage Park
- Museum of Us
- Casa del Rey Moro African Museum
- Coronado Municipal Golf Course
- Mission Beach Vacations
- Black's Beach
- Mission Beach Boardwalk
- Humphreys Concerts by the Bay
- Rock Church
- San Diego Chinese Historical Museum
- Waterfront Park
- Bayshore Bikeway
- Fashion Valley Mall
- Red Spade Theater
- San Diego Vacations
- Mission Basilica San Diego de Alcala
- The Coronado Playhouse
- San Diego Mormon Temple
- North Park Vacations
- Port of San Diego
- San Ysidro Vacations
- American Plaza
- San Diego County Vacations
- Hotel Circle
- Balboa Stadium
- Lyceum Theatre
- San Diego Museum of Art
- Harbor Island Vacations
- Gaslamp Quarter Vacations
- Women's Museum
- Las Americas Premium Outlets
- House of Pacific Relations International Cottages
- Bahia Point Beach
- Clairemont Village Shopping Center
- San Ysidro Border Crossing
- San Diego City College
- Mission Valley Mall
- Kate Sessions Memorial Park
- Centennial Park
- Balboa Park
- Sky Zone San Diego Indoor Trampoline Park
- San Diego Zoo
- Uss Midway Museum
- North Island Credit Union Amphitheatre
- University of San Diego
- White Water Canyon
- Little Italy Vacations
- Star of India
- Sharp Chula Vista Medical Center
- Point Loma Vacations
- Museum of Photographic Arts
- B Street Cruise Ship Terminal
- Downtown San Diego Vacations
- Chula Vista Vacations
- Amsd Concerts
- Naval Base San Diego
- Pechanga Arena
- Len Moore Skate Park
- Desert Garden
- The Promenade at Pacific Beach
- Copley Symphony Hall
- Inez Grant Parker Memorial Rose Garden
- Ocean Beach Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.























