Otay Mesa Vacations from $305

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The Latest Otay Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel
Pantai Inn
Hotel Z
Southern California Beach Club
The Lodge at Torrey Pines

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$130 nightly
The price is $148 total per night from Dec 13 to Dec 14
$148 total
Dec 13 - Dec 14
Total with taxes and fees
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
8.4/10 Very Good! (6,370 reviews)
"The Wyndham San Diego Bayside is very conveniently located. The staff were very welcoming and helpful. The rooms were spacious and comfortable. We loved the walkability to the cruise pier, Little Italy, Seaport Village and transit was close by to get to many points of interest. Highly recommend this ..."

Reviewed on Nov 12, 2026

Wyndham San Diego Bayside
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.