Otay Mesa Vacations from $290

Book a Hotel + Flight or Car together to unlock savings

The Latest Otay Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

Downtown San Diego
$290
per person
Dec 5 - Dec 8
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.6/10 Excellent! (2,586 reviews)
Great hotel

Reviewed on Sep 28, 2026

Hotel Z

Hotel Z

Downtown San Diego
Save 100% on your flight
$356
per person
Dec 5 - Dec 9
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.2/10 Wonderful! (1,167 reviews)
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Mission Valley
Save 100% on your flight
$391
per person
Dec 5 - Dec 9
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.2/10 Wonderful! (3,115 reviews)
Urban Boutique Hotel

Urban Boutique Hotel

Downtown San Diego
Save 100% on your flight
$342
per person
Dec 5 - Dec 9
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.6/10 Excellent! (1,240 reviews)
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Downtown San Diego
Save 100% on your flight
$441
per person
Dec 5 - Dec 9
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9/10 Wonderful! (1,523 reviews)

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
A grand building with a central fountain, palm trees, and a flag.

Downtown San Diego

3 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

A pier extending into calm waters with people on it and a sandy beach with seaweed and a few individuals.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

A sandy beach with a lifeguard tower, ocean waves, and people in the distance.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

A lively street scene with outdoor seating at various bars and restaurants, including 'The Field' and 'Sloppy Joe's'.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

1 out of top 10 points of interest in this area

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Otay Mesa Hotel Deals

Best Western Seven Seas

Best Western Seven Seas

411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
$97 total
Sep 29 - Sep 30
Total with taxes and fees
Best Western Seven Seas
Paradise Point Resort & Spa

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$233 nightly
$268 total
Oct 25 - Oct 26
Total with taxes and fees
8.8/10 Excellent! (2,903 reviews)
"Having the bungalows"

Reviewed on Sep 28, 2026

Paradise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
$211 total
Oct 26 - Oct 27
Total with taxes and fees
8.4/10 Very Good! (6,338 reviews)
"Very good location, check in was fast but not informative regarding parking or location of towers, basic informati on was provided. Receptionist that checked me in was not friendly, seemed like she disliked her job."

Reviewed on Sep 28, 2026

Wyndham San Diego Bayside
See all 4,947 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

$150
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Urban Art Walk from San Diego

Tijuana Urban Art Walk from San Diego

$80
per adult
Tijuana Urban Art Walk from San Diego
Introduction Rosarito Day Tour from San Diego

Introduction Rosarito Day Tour from San Diego

$157
per adult
Introduction Rosarito Day Tour from San Diego
See all activities in San Diego

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.